α-Synuclein aggregation nucleates through liquid–liquid phase separation
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چکیده
منابع مشابه
The Aggregation of Huntingtin and α-Synuclein
Huntington's and Parkinson's diseases are neurodegenerative disorders associated with unusual protein interactions. Although the origin and evolution of these diseases are completely different, characteristic deposits of protein aggregates (huntingtin and α-synuclein resp.), are a common feature in both diseases. After these observations, many studies are performed with both proteins. Some of t...
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Protein misfolding and aggregation is a major hallmark of neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). Until recently, the consensus was that each aggregation-prone protein was characteristic of each disorder [α-synuclein (α-syn)/PD, mutant huntingtin (Htt)/HD, Tau and amyloid beta peptide/AD]. However, growing evidence in...
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ژورنال
عنوان ژورنال: Nature Chemistry
سال: 2020
ISSN: 1755-4330,1755-4349
DOI: 10.1038/s41557-020-0465-9